Combination Therapy Using tPA and Edaravone Improves the Neurotoxic Effect of tPA
نویسندگان
چکیده
منابع مشابه
Synergy of Combined tPA-Edaravone Therapy in Experimental Thrombotic Stroke
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-edaravone therapy is more effective in reducing infarct size than singular treatment is uncertain. Here we investigated this issue using a transient h...
متن کاملUsing TPA for Bayesian inference
Finding the integrated likelihood of a model given the data requires the integration of a nonnegative function over the parameter space. Classical Monte Carlo methods for numerical integration require a bound or estimate of the variance in order to determine the quality of the output. The method called the product estimator does not require knowledge of the variance in order to produce a result...
متن کاملUsing TPA to count linear extensions
A linear extension of a poset P is a permutation of the elements of the set that respects the partial order. Let L(P ) denote the number of linear extensions. It is a #P complete problem to determine L(P ) exactly for an arbitrary poset, and so randomized approximation algorithms that draw randomly from the set of linear extensions are used. In this work, the set of linear extensions is embedde...
متن کاملUsing TPA for Bayesian inference — Discussion
Skilling (2007) previously identified that the number of steps required to reach a given set is Poisson distributed. Huber and Schott suggest making this special case central, recasting all computations as finding the mass of a distribution on a set. Additional contributions are a theoretical analysis, two general ways of reducing problems to the required form and a link to annealing. The resul...
متن کاملConfirmation of tPA treatment effect by baseline severity-adjusted end point reanalysis of the NINDS-tPA stroke trials.
BACKGROUND AND PURPOSE Baseline severity-adjusted end point analysis, an emerging approach to the evaluation of primary end points in acute stroke trials, offers a novel means of adjusting trial analysis for baseline imbalances in presenting stroke severity among treatment groups, a factor that has complicated interpretation and reception of the results of the pivotal National Institute of Neur...
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ژورنال
عنوان ژورنال: Interventional Neuroradiology
سال: 2007
ISSN: 1591-0199,2385-2011
DOI: 10.1177/15910199070130s115